Fig. 5: Dissection of the mechanisms underlying the replicated association between Paraprevotella and the St6galnac1 locus on chromosome 10. | Nature Communications

Fig. 5: Dissection of the mechanisms underlying the replicated association between Paraprevotella and the St6galnac1 locus on chromosome 10.

From: Genetic architecture and mechanisms of host-microbiome interactions from a multi-cohort analysis of outbred laboratory rats

Fig. 5: Dissection of the mechanisms underlying the replicated association between Paraprevotella and the St6galnac1 locus on chromosome 10.The alternative text for this image may have been generated using AI.

A Local association (LocusZoom) plot for ASV_5163 (genus Paraprevotella) measured in the NY cohort and the St6galnac1 locus. Eight genes were omitted for graphical purposes. The y-axis shows the −log10 p-value from an LRT with one degree of freedom comparing a model with a fixed effect for the tested SNP to a null model without (see “Methods” section on GWAS). A wider plot is shown in Supplementary Fig. 11. B Alignment of Illumina short reads from the eight founders of the HS population to the rat reference genome assembly (rn7). C Comparison of the rat reference genome assembly (rn7, from strain BN/NHsdMcwi) and the de novo genome assembly of the strain SHRSP/BbbUtx, which is identical by descent to WN/N at the locus. D–F Genotypic effects on Paraprevotella, A. muciniphila and M. intestinale ASVs that map to the St6galnac1 locus (see Supplementary Table 4). A few outliers were omitted for better visualisation of the quartiles. Given the very small number of rats that were homozygous for the triplication, the association is driven by the difference between the other two genotype groups.

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