Fig. 3: The changes of ExN subgroups in PFC and STP with gestational age. | Nature Communications

Fig. 3: The changes of ExN subgroups in PFC and STP with gestational age.

From: Mid-gestational cell-type-specific transcriptomic signatures in the prefrontal and superior temporal cortex in Down syndrome

Fig. 3: The changes of ExN subgroups in PFC and STP with gestational age.The alternative text for this image may have been generated using AI.

a The model diagram indicates that the PFC and STP in individuals with DS exhibit both overall and localized differential changes. b The trends of standardized cell numbers of different cell types from PFC and STP in the control and DS groups with respect to gestational age. c, d Representative microscopic fields of FOXP2 (green)/SATB2 (red) positive cells in the PFC (b) and STP (c) from GW23 of control and DS. Blue, DAPI. Scale bar, 100 μm. e, f Quantification of FOXP2 (green)/SATB2 (red) positive cells in PFC and STP from Control and DS group. n = 3–4 sections from 3 DS samples or 3 control samples. CP cortical plate, SP subplate zone, MZ marginal zone. Source data are provided as a Source Data file.

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