Fig. 6: Metabolic levels and structural connectivity.

a Example participant: scatter of z-scored 1H-MRSI metabolite levels versus structural node degree (10% edge density). Line shows the ordinary least-squares fit; the shaded band is the 95% confidence interval of the fitted line (bootstrap CI). Spearman’s ρ (p < 0.001) are reported for association. b Group results (n = 41): Spearman correlation between z-scored metabolite levels and degree centrality across structural edge densities. Points show the mean correlation across participants; error bars indicate 95% confidence intervals.