Fig. 4: Statistical analysis across the continuous islet size distribution in human ND, GADA, and T1D pancreas. | Nature Communications

Fig. 4: Statistical analysis across the continuous islet size distribution in human ND, GADA, and T1D pancreas.

From: 3D imaging of human pancreas suggests islet size and endocrine composition influence their loss in type 1 diabetes

Fig. 4: Statistical analysis across the continuous islet size distribution in human ND, GADA, and T1D pancreas.The alt text for this image may have been generated using AI.

A, B INS + GCG-, C, D INS + GCG + , and E, F INS-GCG + EO expressed as A, C, E counts normalized to tissue volume and B, D, F percentage of total EO count. Data are presented as mean ± SD; ND (n = 8), GADA (n = 5), T1D (n = 6). Statistical significance in each EO size category was assessed using one-way ANOVA with Bonferroni’s post hoc test when model assumptions were met, or Kruskal–Wallis test with Dunn’s post hoc test when assumptions were not met (as per Methods). All p-values are two-sided; values < 0.05 were considered statistically significant. For all graphs in this figure gray asterisks show difference between ND and T1D groups, purple asterisks show difference between GADA and T1D groups, p < 0.05 (*), p < 0.01 (**), p < 0.001 (***), p < 0.0001 (****), ND vs GADA p = ns. Exact p-values are provided in the Source Data file. EO – endocrine objects. EO size bins: CC – cell clusters, S – small, M – medium, L – large. Source data are provided as a Source Data file.

Back to article page