Fig. 2: The Pex5-cargo interface shows significant conformational heterogeneity.
From: Structure of Trypanosoma peroxisomal import complex unveils conformational heterogeneity
A Schematic representation of angular tilt of TPR domain of Pex5 relative to the MDH in MP1 (upper panel) and MP2 (lower panel) structures. Superimposed 3D structures of close (colored) and distal (grey) conformations of MP1 (B) and MP2 (C) complex. Color codes in close conformation represent the extent of tilt between distal and close confirmations as explained in the inset. MDH is colored blue in all panels. Pex5 TPR domain is colored according to the discussed features. Refer to Supplementary Fig. 8 for residue-wise RMSD between distal and close orientations.
