Fig. 6: PPARγ target genes are differentially regulated between human developmental stages and diseased states. | Nature Communications

Fig. 6: PPARγ target genes are differentially regulated between human developmental stages and diseased states.

From: Early skin seeding regulatory T cells modulate PPARγ-dependent skin pigmentation

Fig. 6: PPARγ target genes are differentially regulated between human developmental stages and diseased states.

A, B scRNA-seq analysis of skin from healthy donors and vitiligo patients. A UMAP representation of PPARγ target gene expression score. Endothelial endothelial cells, HF hair follicle, IFE interfollicular epidermis, Immune immune cells, LC Langerhans cells, Mel melanocytes, PDGFRA+ Fib PDGFRA+ fibroblasts, PDGFR+ Fib PDGFRB+ fibroblasts. B Quantification of PPARγ score. Fisher’s LSD test. C–E scRNA-seq analysis of foetal, neonatal, and adult melanocytes. C UMAP representation of clusters. D Percentage of cells belonging to individual clusters. Chi-squared test. E Heatmap of PPARγ target gene expression. ****p < 0.0001, **p < 0.01, ns p > 0.05. Source data are provided as a Source Data file.

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