Fig. 2: Identity and clonal relationships of Barrett’s esophagus cell types.
From: Clonal cell states link gastroesophageal junction tissues with metaplasia and cancer
a UMAP of scRNA-seq of all Barrett’s esophagus biopsies, colored by consensus Barrett’s esophagus cell types common to a majority of non-dysplastic Barrett’s esophagus samples. b UMAP of scRNA-seq of all Barrett’s esophagus biopsies, with the cells from each individual biopsy highlighted separately. c Bubble plot of marker genes for Barrett’s esophagus cell types. d UMAPs generated from (b) containing only the cells corresponding to the non-dysplastic Barrett’s esophagus sample indicated. e Heatmaps show the allele frequencies of mtDNA mutations within the Barrett’s esophagus cells in the adjacent UMAP. f UMAP from (d) colored with the allele frequency of a representative mtDNA mutation; stacked bar graph comparing the proportion of Barrett’s esophagus cell types within the representative lineage to their proportion within the entire sample.
