Fig. 7: Detection of damage and chromatin by LIG3α.
From: The zinc finger of DNA ligase 3α binds to nucleosomes via an arginine anchor
a. i Model for how the ZnF-BRCT binds to the nicked DNA. a. ii Model of how CC core complex engages to the nick in the absence of the ZnF. The site of the nick is colored orange. b. i and b. ii Model of full length LIG3a showing dynamic switching between ZnF and CC domains for nick recognition. c Model showing the Arg anchor R62 and R64 (blue) of the ZnF domain (purple) binding to the acidic patch (red) of LIG3α binding to an undamaged 601-NCP. Created in BioRender. Gupta, A. (2025) https://BioRender.com/tfvrtmj. Source data are provided as a Source Data file.
