Fig. 7: Structural models of Q04, CLB, and LLL6E TCR–pMHC complexes in comparison with X-ray structures. | Nature Communications

Fig. 7: Structural models of Q04, CLB, and LLL6E TCR–pMHC complexes in comparison with X-ray structures.

From: Structural insights into clonal restriction and diversity in T cell recognition of two immunodominant SARS-CoV-2 nucleocapsid epitopes

Fig. 7: Structural models of Q04, CLB, and LLL6E TCR–pMHC complexes in comparison with X-ray structures.

X-ray and modeled structures of Q04–SPR–HLA-B7 (a, b), CLB–SPR–HLA-B7 (c, d), LLL6E–LLL–HLA-A2 (e, f) are shown, with models from AlphaFold3 (Q04–SPR–HLA-B7, LLL6E–LLL–HLA-A2) or TCRmodel2 (CLB–SPR–HLA-B7) and represent top-scoring models based on model confidence score. TCRs are colored blue (α chain) and orange (β chain), peptides are magenta (SPR peptide) or cyan (LLL peptide), and MHCs are colored light green (HLA-B7) or dark green (HLA-A2).

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