Fig. 5: APOE ε4 associations with brain change.
From: Vulnerability to memory decline in aging revealed by a mega-analysis of structural brain change
a Association between APOE ε4 (carriers vs. non-carriers) and brain change in the left and right hippocampus (βl[CI] = −0.135[−0.20,−0.07], t(df) = −4.2(3228.1), pFDR = 0.004, n = 3310; βr[CI] = −0.138[−0.20,−0.07], t(df) = −4.1(3261.1), pFDR = 0.003, n = 3297), and the right amygdala β[CI] = −0.154[−0.22,−0.09], t(df) = −4.7(3249), pFDR = .001, n = 3302) assessed with linear mixed model. b Effect of APOE ε4 on brain change across all regions (h0 = 0; β = −0.004, t(df) = −1.30(165), p = .20, n = 166) assessed using a one-sample t-test. Each point represents a region. Note that the three regions with more negative effects of APOE ε4 correspond to those displayed in panel a). Boxes represent the interquartile range (IQR), and whiskers extend to 1.5 × IQR. Line represents the median. Distribution of values outside whiskers can be assessed in the contiguous density plots.
