Fig. 6: G6374 selectively inhibits IRE1-dependent cancer-cell proliferation regardless of the underlying mode of dependency. | Nature Communications

Fig. 6: G6374 selectively inhibits IRE1-dependent cancer-cell proliferation regardless of the underlying mode of dependency.

From: Chemically-induced degradation of the endoplasmic-reticulum stress sensor IRE1 by a VHL-recruiting chimera

Fig. 6: G6374 selectively inhibits IRE1-dependent cancer-cell proliferation regardless of the underlying mode of dependency.The alt text for this image may have been generated using AI.

Incucyte data (plotted with at least three replicates, mean ± SD) for OPM2 (a), AMO1 (b), KMS27 (c), U2OS (d), or Colo201 (e) cells expressing Dox-inducible shRNA against IRE1, treated with a titration of G6374. Dox is used at 0.2 µg/mL as a control for IRE1 depletion.

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