Fig. 2: Simultaneous mouse iEEG-fMRI revealed consistent inverted U-shaped relationship between arousal and whole-brain FC as in human. | Nature Communications

Fig. 2: Simultaneous mouse iEEG-fMRI revealed consistent inverted U-shaped relationship between arousal and whole-brain FC as in human.

From: Norepinephrine-mediated arousal fluctuations drive inverted U-shaped functional connectivity dynamics

Fig. 2

A Simultaneous iEEG-fMRI in non-anesthetized mice (n = 46 sessions) captured a broad spectrum of arousal dynamics across awake and non-rapid eye movement (NREM) sleep states. EMG electromyography. B Arousal modulated inverted U-shaped whole-brain FC dynamics in awake mice. The dynamic FCs were fitted to a quadratic curve y = β2x2 + β1x + β0, and the β2 < 0 represented an inverted U-shaped profile. Black solid line (or shade), the best fitting of quadratic curve (or the 95% prediction interval). Sample size n = 46 runs for each bin. Error bar, the standard error of the mean (SEM). C Quantitative evaluations of arousal aligned FC dynamics. Sample size n = 10 bins for each arousal level. Error bar, the SEM. Statistical significance was determined by the paired t-test (two tails). n.s. no significance; *, p < 0.05, **, p < 0.01. D Arousal modulated whole-brain spatial pattern of global FC changes in mice. Source data are provided as a Source Data file.

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