Fig. 8: LC-NE mediated arousal fluctuations drive inverted U-shaped functional connectivity dynamics. | Nature Communications

Fig. 8: LC-NE mediated arousal fluctuations drive inverted U-shaped functional connectivity dynamics.

From: Norepinephrine-mediated arousal fluctuations drive inverted U-shaped functional connectivity dynamics

Fig. 8

LC-NE activity and resulting extracellular NE concentrations increased with arousal in awake state, and contributed to the inverted U-shaped global FC dynamics. Based on up and downregulations on LC-NE neurons, the baseline arousal largely determined the NE-mediated inverted U-shaped global FC dynamics.

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