Fig. 5: Bacterially-derivedĀ N1-Animopropylagmatine accumulates in host cells and disruptsĀ mitochondrial function. | Nature Communications

Fig. 5: Bacterially-derivedĀ N1-Animopropylagmatine accumulates in host cells and disruptsĀ mitochondrial function.

From: A noncanonical polyamine from bacteria antagonizes host mitochondrial function

Fig. 5: Bacterially-derivedĀ N1-Animopropylagmatine accumulates in host cells and disruptsĀ mitochondrial function.The alternative text for this image may have been generated using AI.

N1-Aminopropylagmatine accumulates in the C.Ā elegans intestinal lumen when the animals are grown on a diet of B. subtilis āˆ†speB. CATP-5 transports N1-APA into intestinal cells where it inhibits eIF5a hypusination. N1-APA antagonizes mitochondrial and immune function. Image was created in BioRender [Nauta, K. (2025) https://BioRender.com/wh83sde] and ChemDraw.

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