Fig. 3: B cell depletion enhances the anti-tumor efficacy of immunotherapy and decreases metastasis in the murine HCA-1 HCC model. | Nature Communications

Fig. 3: B cell depletion enhances the anti-tumor efficacy of immunotherapy and decreases metastasis in the murine HCA-1 HCC model.

From: Inhibiting B cells enhances the efficacy of STING agonism or immune checkpoint blockade in hepatocellular carcinoma

Fig. 3: B cell depletion enhances the anti-tumor efficacy of immunotherapy and decreases metastasis in the murine HCA-1 HCC model.The alternative text for this image may have been generated using AI.

a Experimental design using the orthotopic HCA-1 murine HCC model. b Tumor growth kinetics after treatment: the combination of dual PD-1/VEGFR2 blockade and B-cell depletion group induced tumor growth delay superior to other groups. n = 10/group. c Overall survival of HCC-bearing mice after treatment: Combination of dual PD-1/VEGFR2 blockade plus B cell depletion induced a significant survival benefit to other groups. P-value from log-rank test, n = 10/group. d Experimental design of B cell depletion with STING agonist treatment. e Tumor growth kinetics after treatment: the combination of STING agonist and B cell depletion group induced tumor growth delay superior to other groups. n = 8 for IgG control and STING+IgG groups, n = 9 for STING+aCD19 + aB220 group. f Overall survival of HCC-bearing mice after treatment: STING agonist plus B cell depletion induced a significant survival benefit than STING alone or IgG control groups. P-value from log-rank test, n = 8 for IgG control and STING+IgG groups, n = 9 for STING+aCD19 + aB220 group. g STING agonism/B cell depletion reduced lung metastasis rates. n = 8 for IgG control and STING+IgG groups, n = 9 for STING + aCD19 + aB220 group. h Representative photographs of lungs after fixation in Bouin’s solution and STING agonism/B cell depletion combined treatment significantly reduced lung metastasis in the HCA-1 murine HCC model. P-value from one-way ANOVA with the Tukey multiple comparisons test, n = 8 for IgG control and STING + IgG groups, n = 9 for STING + aCD19 + aB220 group. Data from the box plot are presented as mean ± SD. Source data are provided as a Source Data file.

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