Table 1 FoldSeek relevant top hits with similar folding to the predicted SPV_0647 structure
PDB ID | Bit score | E-value | Probability | Name | Organism | Notes | Reference |
|---|---|---|---|---|---|---|---|
4MK6 | 233 | 7.54 × 10−6 | 1.00 | DHSK_reg | Listeria monocytogenes | Probable dihydroxyacetone (glycerone) kinase regulator |  |
5NZ1 4DW6 5F27 5NZ0 3Q0V 6HO0 5NIM 5MYM 6HO6 | 187 186 185 185 181 179 175 167 161 | 1.28 × 10−4 1.55 × 10−4 4.37 × 10−5 9.54 × 10−5 1.05 × 10−4 1.48 × 10−4 2.16 × 10−4 2.41 × 10−4 6.40 × 10−4 | 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 | EthR | Mycobacterium tuberculosis | Bound and allosterically regulated by medium-chain saturated fatty acid hexadecyl octanoate | Frénois et al.89 |
2IU5 | 171 | 6.72 × 10−4 | 1.00 | DhaS | Lactococcus lactis | Dihydroxyacetone kinase activator | Christen et al.90 |
6O6N 6O6O | 161 158 | 1.09 × 10−3 1.33 × 10−3 | 1.00 1.00 | FasR | Mycobacterium tuberculosis | Activator binds long fatty acyl-CoA | Lara et al. 91 |
3LSJ | 156 | 1.54 × 10−3 | 1.00 | DesT | Pseudomonas aeruginosa | Binds both unsaturated and saturated fatty acids, regulating their ratio | Zhang et al. 92 |
6OF0 | 155 | 6.40 × 10−4 | 1.00 | MtrR | Neisseria gonorrhoeae | Regulates hydrophobic substrate efflux, hydrophobic binding pocket | Beggs et al. 93 |
5D1W | 153 | 8.57 × 10−4 | 1.00 | Rv3249c | Mycobacterium tuberculosis | Regulates MmpL-mediated lipid export, binds palmitic acid | Delmar et al. 94 |
3WHC | 152 | 1.21 × 10−3 | 1.00 | FadR | Bacillus subtilis | Binds long-chain acyl-CoAs, shown for stearoyl-CoA | Fujihashi et al. 95 |
