Fig. 1: Scheme of the study design.
From: Human plasma proteomic profile of clonal hematopoiesis
We assessed the associations of CHIP and driver gene-specific CHIP subtypes (DNMT3A, TET2, ASXL1, and JAK2) with 1148 circulating proteins quantified by the SomaScan platform in 12,911 participants from TOPMed cohorts and 2923 circulating proteins quantified by Olink in 49,217 participants from UK Biobank. Causal relations for the associations were examined through genetic causal inference using Mendelian randomization and murine experiments contrasting plasma protein levels between Tet2+/+ mice and control mice using ELISA. Pathway analyses were conducted using IPA tools. Finally, we investigated the associations between prevalent CAD and proteomics, identifying shared proteins associated with both CAD and any examined CHIP variable. CAD Coronary artery disease, CHIP Clonal hematopoiesis of indeterminate potential, TOPMed Trans-Omics for Precision Medicine, ELISA enzyme-linked immunosorbent assay. Parts of this figure have been created with BioRender.com.
