Fig. 4: Associations between CHIP mutations and circulating proteome quantified by Olink in UK Biobank. | Nature Communications

Fig. 4: Associations between CHIP mutations and circulating proteome quantified by Olink in UK Biobank.

From: Human plasma proteomic profile of clonal hematopoiesis

Fig. 4: Associations between CHIP mutations and circulating proteome quantified by Olink in UK Biobank.The alternative text for this image may have been generated using AI.

A All participants (N = 41,022). B Male participants only (N = 18,831) vs. Female participants only (N = 22,191). Proteins that are associated at FDR = 0.005 level (for 11,668 testings) are labeled with the corresponding Olink targets and colored in blue, red, purple, and green, indicating significant associations with composite CHIP, DNMT3A, TET2, and ASXL1, respectively. Associations were assessed through linear regression models adjusting for age at sequencing, sex, self-reported British White ancestry (if applicable), type 2 diabetes status, current smoker status, first ten principal components of genetic ancestry, and 150 PEER factors. CHIP Clonal hematopoiesis of indeterminate potential, FDR False discovery rate, PEER Probabilistic estimation of expression residuals.

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