Fig. 6: ELISA results of Tet2−/− and WT mice by sex for selected plasma proteins whose level changes are associated with and causal by TET2 in human. | Nature Communications

Fig. 6: ELISA results of Tet2−/− and WT mice by sex for selected plasma proteins whose level changes are associated with and causal by TET2 in human.

From: Human plasma proteomic profile of clonal hematopoiesis

Fig. 6: ELISA results of Tet2−/− and WT mice by sex for selected plasma proteins whose level changes are associated with and causal by TET2 in human.The alternative text for this image may have been generated using AI.

A A protein of which the causal role of TET2 is supported in both SomaScan and Olink, LCN2. B A protein of which the causal role of TET2 is supported in SomaScan only, MPO. C A protein of which the causal role of TET2 is supported in Olink only, Flt3l. Data are presented as mean values ± SEM, with each point representing a single biological replicate (one mouse). For each experimental group (defined by Tet2−/− vs WT and sex), sample sizes ranged from 8 to 10 mice, based on availability at the time of the experiment. Statistical significance was determined using a two-way ANOVA. Significance is indicated as **P < 0.05, ***P < 0.01, and ****P < 0.0001; NS not significant, Flt3l FMS-related tyrosine kinase 3 ligand, LCN Lipocalin 2, MPO Myeloperoxidase, WT wild-type.

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