Fig. 7: Binding sites of Compounds 1, 3, and 6.
From: WRN structural flexibility showcased through fragment-based lead discovery of inhibitors
A Two copies of compound 1 (pale blue) bound to WRN Form D, with one copying overlaying with fragment 1. Interactions between the two compound 1 copies and WRN are shown in yellow dashes. Residues Val552, Tyr849, and Phe917 are nearby compound 1 trifluoromethyl. B Compound 3 (salmon) is shown overlaid with compound 1 (pale blue). Interactions between compound 3 and WRN are shown in yellow dashes. C Compound 6 (yellow) overlaid with compound 3 (salmon). Interactions between compound 6 and WRN are shown in yellow dashes.
