Fig. 9: Comparison of WRN conformations Form A, D, and E.
From: WRN structural flexibility showcased through fragment-based lead discovery of inhibitors
The three forms highlighted here aligned on D1 domains, with Form A in gray, Form D in blue, and Form E in green. The differences in domain configurations can be thought of as rotations around the linker residues connecting D1 and D2. Each structure has a red oval covering the same C-terminal helix containing residues Phe888-His904 to help orient and visualize these rotations. A An approximate 180° rotation of D2 domains is seen between Form A and Form D. B There is also an approximate 180° rotation of the D2 domains between Form A and Form E (green). However, the rotation axis is different than that seen between Form A and Form D. C Form D and Form E structures differ by a rotation of approximately 90° around the linker.
