Fig. 4: Survival associations with individual bacterial taxa. | Nature Communications

Fig. 4: Survival associations with individual bacterial taxa.

From: Microbiome analysis of 940 lung cancers in never-smokers reveals lack of clinically relevant associations

Fig. 4

a Cox proportional hazard model of ten-year survival with RNA-seq bacterial relative abundances including genera with minimum 50 reads in 10% of samples, b 16S bacterial relative abundances including genera with minimum 10 reads in 10% of samples, and c meta-analyzed WGS bacterial relative abundances, including genera with minimum 10 reads in 10% of samples. All analyses were stratified by study site, age at diagnosis (age >65 or ≤65), and stage (stage I or stages II–IV), and further adjusted by histology and age in ten year categories. All associations are not significant (FDR > 0.05) after multiple testing correction. Points represent log Cox hazard ratio, error bars signify standard error. RNA-seq n = 587 tumor samples, 482 normal samples; 16S n = 488 tumor samples, 395 normal samples; WGS n = 647 tumor samples, 375 blood samples. WGS whole genome sequencing, Rna-seq RNA sequencing, 16S 16S rRNA gene sequencing.

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