Fig. 2: Landscape of somatic mutations in the NMF molecular subtypes.
a Oncoplot of genes that had mutations and copy number variations in ≥ 2% of 261 tumour samples used in whole-exome sequencing analyses. b Oncoplots for the four NMF subtypes, showing genes altered in ≥ 10% of samples in the same order as in Fig. 2a. c FDR-adjusted P values from a Pearson’s χ2 test are reported for comparisons of mutations in each indicated gene among samples. d Percentage of NSCLC samples carrying variations in each gene by NMF subtype. The proportions of each molecular subtype with available whole exome sequencing data were 37 NMF1 samples (35.9%), 84 NMF2 samples (46.2%), 73 NMF3 samples (46.8%), and 65 NMF4 samples (54.6%). e Tumour mutation burden (TMB) in each NMF subtype. The lower and upper hinges in the box plot correspond to the first and third quartiles. The upper whisker extends from the hinge to the largest value no further than 1.5× IQR from the hinge (where IQR is the interquartile range, or distance between the first and third quartiles). The lower whisker extends from the hinge to the smallest value at most 1.5× IQR of the hinge. There were 37 samples in NMF1, 85 samples in NMF2, 73 samples in NMF3, and 65 samples in NMF4. Source data are provided as a Source Data file. Two-sided t-test was used for pairwise comparison. P values were 0.128 (NMF2 vs NMF4), 0.6238 (NMF3 vs NMF1), 0.6907 (NMF4 vs NMF1), 0.0038 (NMF3 vs NMF2), 0.0016 (NMF4 vs NMF2), 0.9396 (NMF4 vs NMF3). *P < 0.05; **P < 0.01; ***P < 0.001.
