Fig. 4: Thalamic matrix-cell richness and behavioral outcome changes during LIFU.
Correlations between matrix-cell richness (CPT; x-axis) and behavioral outcome changes compared to baseline (y-axis) are shown for (a, b) 70% and c 5% DC, including (a) sensitivity d’, b categorization accuracy for real images, and c criterion c. CPT reflects the weighted difference between calbindin-1 (CALB1) and parvalbumin (PVALB) expressions. Positive and negative CPT values indicate matrix- and core-cell richness at the beam-present regions (voxels exceeding 50% relative intensity), respectively. Statistical associations were assessed using two-sided Spearman’s rank correlation (ρ), with p-values adjusted for multiple comparisons using FDR method at α = 0.05 across the three behavioral measures. Circle colors indicate target regions. Solid lines and shades show linear fits and 95% confidence intervals for visualization only. VA ventroanterior thalamus, VP ventroposterior thalamus, DA dorsoanterior thalamus, DP dorsoposterior thalamus. Statistics and source data are provided as a Source Data file.
