Fig. 8: Mapping of XP, CS, and TTD disease mutations onto the XPD structural model. | Nature Communications

Fig. 8: Mapping of XP, CS, and TTD disease mutations onto the XPD structural model.

From: Translocation mechanism of xeroderma pigmentosum group D protein on single-stranded DNA and genetic disease etiology

Fig. 8

a Schematic representation of disease-associated mutation sites along the XPD sequence, highlighting mutations linked to xeroderma pigmentosum (XP, black), combined XP and Cockayne syndrome phenotype (XP/CS, pink), trichothiodystrophy (TTD, green), combined XP and TTD phenotype (purple), and overlapping XP/TTD sites (purple star). b Positioning of disease mutations in the XPD structural model. c Zoomed-in view of mutations lined up along the ATPase cleft of XPD.

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