Fig. 4: Changes in fecal microbiome and metabolome are associated to the nutritional intervention and clinical outcomes.

A Correlations between metagenome, metabolome and clinical outcomes (see methods for more details on the statistical approach). Comparison of in handgrip force (B), tibia SOS (C), and Vitamin D (D) between samples showing an increase in L. reuteri after 6 months compared to baseline (“Increase”, n = 37) and samples not showing an increase (“Non-increase”, n = 101). Non-significant associations are shown in Supplementary Data 14.