Fig. 3: Selection of autoantibodies of clinical relevance. | Nature Communications

Fig. 3: Selection of autoantibodies of clinical relevance.

From: Autoantibody landscape and functional role of anti-C-C motif chemokine receptor 8 autoantibodies in systemic sclerosis: post-hoc analysis of a B-cell depletion trial

Fig. 3: Selection of autoantibodies of clinical relevance.

A Volcano plot that shows autoantibodies differentially elevated in SSc before treatment compared to healthy controls (HCs). The horisontal dashed line indicates P = 0.05. B Volcano plot that shows autoantibodies differentially increased in HRs than in LRs. C Volcano plot that shows autoantibodies significantly reduced in HRs during RTX therapy. D Heat map that shows the serum levels of 58 candidate autoantibodies of clinical relevance. E Principal component analysis of 58 candidate autoantibodies of clinical relevance. In the scatter plot, individual subjects as points. F The loading diagram illustrates the contributions to PC1 and PC2.

Back to article page