Fig. 9: Gene set enrichment analysis and ingenuity pathway analysis of bleomycin-induced systemic sclerosis mouse model. | Nature Communications

Fig. 9: Gene set enrichment analysis and ingenuity pathway analysis of bleomycin-induced systemic sclerosis mouse model.

From: Autoantibody landscape and functional role of anti-C-C motif chemokine receptor 8 autoantibodies in systemic sclerosis: post-hoc analysis of a B-cell depletion trial

Fig. 9: Gene set enrichment analysis and ingenuity pathway analysis of bleomycin-induced systemic sclerosis mouse model.

A Heatmap showing significant Hallmark pathways and the top 10 enriched Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways from Gene Set Enrichment Analysis (GSEA). B Ingenuity Pathway Analysis (IPA)-predicted Disease and Bio-functions with |z score | ≥ 2 in at least one group were included for visualization. Notably, inflammation- and cell movement–related functions are prominently activated in the bleomycin (BLM) + anti-C-C motif chemokine receptor 8 (CCR8) Ab group. C Interaction networks of the top two activated biological functions in the BLM + anti-CCR8 antibody (Ab) vs. phosphate buffer saline (PBS) group, including “Cell movement of myeloid cells” and “Cell movement of granulocytes.” The disease categories “Fibrosis” and “Fibrotic disorder of skin” also show higher enrichment in the BLM + anti-CCR8 Ab group compared to the BLM + Ctrl IgG group, suggesting a stronger fibrotic response modulated by anti-CCR8 Ab treatment.

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