Table 1 Baseline characteristics of the human subjects
SSc on RTX | SSc on placebo | HC | |
|---|---|---|---|
(n = 24) | (n = 21) | (n = 45) | |
Basic features | |||
Sex | |||
Female | 22 (91.7%) | 19 (90.5%) | 41 (91.1%) |
Male | 2 (8.3%) | 2 (9.5%) | 4 (8.9%) |
Age, years | 48.79 (15.50) | 49.24 (9.66) | 44.09 (14.05) |
Disease duration, months | 96.75 (73.75) | 77.29 (64.69) | NA |
mRSS | 13.58 (3.26) | 15.67 (5.43) | NA |
ILD presence | 24 (100.0%) | 19 (90.5%) | NA |
ILD severity | 1.25 (0.44) | 1.05 (0.50) | NA |
Pulmonary function | |||
%FVC | 87.42 (15.91) | 90.19 (18.61) | NA |
%DLco | 84.55 (19.63) | 83.12 (14.56) | NA |
Laboratory tests | |||
SP-A, ng/mL | 40.81 (25.81) | 43.45 (29.76) | NA |
SP-D, ng/mL | 153.11 (80.93) | 165.99 (133.82) | NA |
KL-6, U/mL | 771.42 (759.63) | 667.10 (720.64) | NA |
BNP, ng/mL | 32.71 (58.86) | 23.33 (13.92) | NA |
IgA, mg/mL | 205.29 (65.69) | 229.81 (85.52) | NA |
IgG, mg/mL | 1349.12 (371.67) | 1421.71 (548.83) | NA |
IgM, mg/mL | 127.75 (44.68) | 94.52 (39.89) | NA |
Seum autoantibody levels | |||
ATA, U/mL | 80.24 (65.11) | 69.91 (67.25) | NA |
ACA, U/mL | 22.75 (49.80) | 19.08 (40.08) | NA |
ARA, U/mL | 20 ± 37 | 17 ± 37 | NA |
RNP, U/mL | 20.26 (36.67) | 16.63 (36.60) | NA |
SF-36 score | |||
Bodily pain | 62.67 (26.35) | 58.48 (24.37) | NA |
General health | 46.71 (14.01) | 46.14 (14.87) | NA |
Mental health | 70.00 (19.45) | 70.24 (19.40) | NA |
Physical functioning | 80.83 (15.99) | 75.71 (15.83) | NA |
Role, emotional | 80.90 (25.83) | 79.76 (28.33) | NA |
Role, physical | 69.79 (25.65) | 71.43 (21.34) | NA |
Social functioning | 79.17 (26.50) | 81.55 (15.11) | NA |
Vaitality | 48.44 (25.29) | 51.49 (15.55) | NA |
HAQ-DI score | |||
total | 0.32 (0.48) | 0.45 (0.41) | NA |
HAQ1 (dressing and grooming) | 0.29 (0.62) | 0.38 (0.50) | NA |
HAQ2 (arising) | 0.04 (0.20) | 0.19 (0.40) | NA |
HAQ3 (eating) | 0.58 (0.93) | 0.90 (0.89) | NA |
HAQ4 (walking) | 0.04 (0.20) | 0.24 (0.44) | NA |
HAQ5 (hygiene) | 0.12 (0.34) | 0.19 (0.40) | NA |
HAQ6 (reach) | 0.38 (0.71) | 0.43 (0.68) | NA |
HAQ7 (grip) | 0.62 (0.82) | 0.71 (0.64) | NA |
HAQ8 (common daily activities) | 0.38 (0.82) | 0.52 (0.81) | NA |
