Fig. 6: Mesenchymal tumor cells, differing in distinct gene expression programs, prevail in spatially separated glioma niches.
From: Pericytes orchestrate a tumor-restraining microenvironment in glioblastoma
A VGES capture area images of 4 Pdgfbret/+ (black label) and 4 Pdgfbret/ret (red label) glioma sections (upper and lower panels), colored by the mean Z-scores of the scRNA-seq clusters MES I and II. The middle panels show the corresponding immunostainings of PIM and Ki67 for each section. B Violin plots showing the signature score of HSS (hypoxia and stemness) and ISS (invasiveness) across all scRNA-seq clusters for Pdgfbret/ret and Pdgfbret/+ tumor-derived cells. Pdgfbret/+ is depicted in black and Pdgfbret/ret in red. C Image of a Pdgfbret/ret glioma section (#1159) colored by the signature score of HSS (hypoxia and stemness) and ISS (invasiveness). D Spatial scatterpie chart of glioma sections #1070 (Pdgfbret/+) and #1159 (Pdgfbret/ret), showing the RCTD-inferred proportions of different cell types per spot. Source data are provided as a Source data file.
