Fig. 2: Pre-existing cross-reactive antibody levels are poorly predictive of protection against infection but correlate with delayed onset of viral shedding. | Nature Communications

Fig. 2: Pre-existing cross-reactive antibody levels are poorly predictive of protection against infection but correlate with delayed onset of viral shedding.

From: Pre-existing and early cellular immune factors correlate with functionally complete protection against primary controlled human SARS-CoV-2 infection

Fig. 2: Pre-existing cross-reactive antibody levels are poorly predictive of protection against infection but correlate with delayed onset of viral shedding.

a Plasma and b mucosal lining fluid IgG, IgM and IgA against hCoVs 229E, HKU1, NL63 and OC34 spike, SARS-CoV-1 spike and SARS-CoV-2 spike and nucleocapsid in the infected (n = 18) and uninfected (n = 16) groups measured at baseline (day −1) by MSD (transiently infected shown as grey triangles, n = 5). c Correlation matrix heatmap showing Spearman correlations between baseline antibody level and time to qPCR positivity in days corrected for multiple comparisons by false discovery rate (FDR). d Two-sided spearman correlation between time to qPCR positivity and duration of qPCR positivity in days. Median lines and IQR are shown. Two-sided multiple Mann–Whitney unpaired tests corrected for multiple antigen and isotype comparisons (Holm-Šídák’s) was used to show significance between the two groups. *p < 0.05.

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