Fig. 7: Human APOBEC3A is spatially coexpressed with urothelial carcinoma cells with squamous differentiation.

A XeniumRanger processed image of a urothelial carcinoma tumor with 5–10% squamous differentiation. Epithelial cells were pseudo-colored based on XeniumRanger clustering assignment (Cluster K2 = blue, Cluster K4 = red, Cluster K5 = brown). B H&E of a region of interest (ROI) containing a squamous cell population aligning with the Cluster K4 cells. C Transcript density (top) and transcript quantification by cluster (bottom) for the indicated gene within the ROI. D Heatmap visualizing the relationship between the Cluster assignments and the gene expression for canonical cell markers. Expression is represented by the per-cluster mean transcript count for the indicated gene, calculated for the entire section. E Bar graph of the total number of cells (whole section) triple-positive for KRT6A, IVL, and DSG3 while also co-expressing APOBEC3A, APOBEC3B, or both (A3A and A3B). See data availability statement for source data.