Fig. 7: In vivo anti-infectious efficacy of PBGProOx₂₀ in a mice model of peritonitis.

a Schematic representation of the peritonitis model. The infected mice were treated intraperitoneally with saline, PBGProOx₂₀ (40 mg/kg), vancomycin (40 mg/kg) or imipenem (40 mg/kg) for once application. b Survival rates of infected mice after treatment with saline, PBGProOx₂₀, vancomycin or imipenem in the peritonitis model (n = 6). The mice were infected by S. aureus, S. epidermidis, E. coli and A. baumannii, respectively. The survival benefit was determined using a log-rank test. ^**P < 0.01, ^***P < 0.001. Bacterial load in different organs, blood, and peritoneal fluid in the peritonitis model induced by S. aureus (c), S. epidermidis (d), E. coli (e) and A. baumannii (f), respectively (n = 6). g Histological analysis by H&E staining of various organs sections from the S. aureus-infected mice after the treatment with saline, vancomycin and PBGProOx₂₀. Black arrows and circles represent histological anomalies. Data are presented as mean ± SD in c–f. Statistical analysis was conducted using one-way ANOVA with multiple comparisons using Tukey’s post-test in c–f. ^*P < 0.05, ^**P < 0.01, ^***P < 0.001. Exact p values are provided in Source Data.