Fig. 3: LRRC8A:D VRACs are closed by pore lipids.
From: Assembly and lipid-gating of LRRC8A:D volume-regulated anion channels
a Side-view (top) and bottom-view slice (bottom) of the LRRC8A:D model with pore (salmon, darker) and annular (salmon, lighter) lipids highlighted. b Side-view slices of the LRRC8A:D model (top) and carved map density (bottom) with pore and annular lipids highlighted. c Left: side-view slice of the LRRC8A:D model pore with lipids and the pore surface (blue) highlighted. Right: Calculated pore radii in the presence (blue, solid line) and absence (gray, dashed line) of pore lipids.
