Fig. 1: A flowchart outlining the study overview and approach.
From: Circulating causal protein networks linked to future risk of myocardial infarction
The schematic outlines the analytical pipeline, beginning (left) with the AGES prospective population-based cohort, which provided comprehensive phenotype and genotype information, proteomic profiles and cis-acting pQTL data. Subsequent steps included reconstructing 185 causal protein networks, each comprising 10 or more targets, via Mendelian randomization analysis, and evaluating associations between network regulators and eigenproteins with ACVD-related phenotypes, and finally (right), ranking CPN subnetworks by their connectivity to incident MI and related traits, revealing their hierarchical organization.
