Fig. 4: Comparison of association P-values for regulators and eigenproteins with myocardial infarction and related traits.
From: Circulating causal protein networks linked to future risk of myocardial infarction
Scatterplots (a–f) display the correlation of association P-values between 182 network regulators and their corresponding network eigenproteins (first principal component, explaining > 15% of variance) for myocardial infarction (MI) and cardiometabolic traits contributing to atherosclerotic cardiovascular disease (ACVD), represented as -log10(P-values). The relationship between serum protein (and eigenprotein) levels and quantitative phenotypes was evaluated using linear regression controlling for age and sex, whilst the relationship between serum proteins (and eigenproteins) and prevalent disease was examined cross-sectionally using logistic regression with age and sex adjustments. The associations between serum proteins (and eigenproteins) and incident disease were evaluated longitudinally using the Cox proportional-hazards model. Red dashed lines mark the 5% FDR thresholds for the respective axes.
