Fig. 5: Intersection and clustering of subnetworks linked to myocardial infarction and related traits.
From: Circulating causal protein networks linked to future risk of myocardial infarction
The UpSet plots illustrate the intersections of the 182 causal protein networks (CPN) related to incident myocardial infarction (MI) and related cardiometabolic trait associations with (a) the network regulators (FDR ≤ 5%) and (b) the CPN eigenproteins (FDR ≤ 5%). The heatmaps on the right depict the relationship between the top-ranked subnetworks (c) network regulators and (d) eigenproteins and MI-related outcomes. Blue squares indicate a negative relationship between network regulators or eigenproteins and the outcome, while red squares represent a positive relationship. A star within a box denotes a significant association between proteins and outcome, based on an FDR estimate of < 5%. CAC coronary artery calcium, Plaque carotid artery plaque burden, T2D type 2 diabetes (prevalent), MetS metabolic syndrome, MI incident myocardial infarction, HF incident heart failure.
