Fig. 6: Interconnectivity between the top ranked causal protein networks associated with myocardial infarction and/or related traits.

a Network visualization of the interconnections among the top ranked causal protein networks (CPN) for incident myocardial infarction (MI) and associated traits, where the variance explained by network eigenproteins is over 15% (see Table 2). Red nodes represent network regulators, while blue nodes denote target proteins. b Heatmap displaying the similarity between CPN subnetworks. The upper right triangle shows hierarchical clustering based on pairwise Pearson correlations between network eigenproteins. The clustering leaf order of the Pearson correlations has been applied to the lower left triangle, which represents pairwise Jaccard Index scores between the same networks. c Hierarchical representation of interacting network regulators where color indicates degree of association with incident MI. Red = both eigenprotein and network regulator are significantly (FDR < 0.05) linked to incident MI, orange = either eigenprotein or network regulator associated with MI, and blue = no association to incident MI.