Table 2 The top ranking (score ≥ 7) causal protein networks related to incident MI and associated traits

From: Circulating causal protein networks linked to future risk of myocardial infarction

Protein regulatory network

Network versus MI-related trait relationships*

Score

Network regulator

Number of B-proteins

CAC

Plaque severity

MetS

T2D

MI

HF

ITIH3

11

2

2

2

1

2

2

11

HSPA1B

13

2

0

2

2

2

2

10

DDX39B

36

2

0

2

2

2

2

10

HSPA1A

19

2

0

2

2

2

2

10

KEAP1

12

2

1

2

1

1

2

9

C2

32

1

1

2

2

1

2

9

PCDH8

131

2

0

2

1

2

2

9

GABARAP

143

2

1

1

1

2

2

9

CSH1 | CSH2

19

2

1

2

1

1

1

8

RFC4

13

1

0

1

2

2

2

8

IZUMO1

24

2

0

1

1

2

2

8

CSF3

10

1

0

2

1

2

2

8

FABP3

98

1

1

1

1

2

2

8

KLKB1

18

1

1

1

1

2

1

7

DCTN2

19

1

0

2

1

1

2

7

AFM

19

0

0

2

2

1

2

7

AIPL1

138

2

1

1

0

1

2

7

MRRF

251

2

0

1

1

1

2

7

APOA5

19

1

0

2

2

1

1

7

PTPN11

83

1

0

2

1

1

2

7

CFB

97

1

1

2

2

0

1

7

GAL3ST1

42

0

1

2

2

1

1

7

NUDT21

396

1

1

1

1

1

2

7

COL28A1

478

1

1

1

1

1

2

7

C11orf49-LRP4

1208

1

1

2

1

1

1

7

  1. *Linear, logistic, or Cox regression analysis was used depending on whether the traits were continuous, prevalent categorical, or incident categorical, respectively. Scoring: neither network regulator nor eigenprotein associated with the trait = 0; network regulator or eigenprotein (PC1 ≥ 15% variance explained) associated with the trait = 1; both network regulator and eigenprotein linked to the trait = 2. Statistical significance for network regulators was determined using the Benjamini-Hochberg adjusted FDR with a P-value threshold of < 0.05. For eigenprotein associations with traits, a Bonferroni-adjusted P-value threshold of < 0.00027 was applied.
  2. CAC coronary artery calcium, Plaque severity, carotid plaque severity score; MetS metabolic syndrome, T2D type 2 diabetes (prevalent), MI myocardial infarction (incident), HF heart failure (incident).
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