Fig. 3: Poor recovery of effector memory T cells in RMs treated with cART or cART + 3HP. | Nature Communications

Fig. 3: Poor recovery of effector memory T cells in RMs treated with cART or cART + 3HP.

From: Concurrent TB and HIV therapies control TB reactivation during co-infection but not chronic immune activation

Fig. 3: Poor recovery of effector memory T cells in RMs treated with cART or cART + 3HP.

We immunophenotyped the partially reconstituted pulmonary CD4+ and CD8+ T cells in cART (n = 4) or cART+3HP-treated RMs (n = 6) into CD+TCM and CD4+TEM populations. Percentage of A CD4+ TCM, B CD4+ TEM, C CD8+ TCM and D CD8+ TEM were measured in BAL of cART+3HP-treated RMs (n = 6) at pre-infection, weeks 3, 11 and 24 post Mtb-infection. Significance was determined using a two-tailed Student’s t test. We compared the percentage of E BAL CD4+ TCM, F lung CD4+ TCM, G BAL CD4+ TEM, H lung CD4+ TEM, I BAL CD8+ TCM, J lung CD8+ TCM, K BAL CD8+ TEM, L lung CD8+ TEM in cART versus cART+3HP-treated RMs at necropsy. Significance was determined using one-way ANOVA with Sidak’s or Tukey’s correction as applicable. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001. Data are presented as mean ± SEM. Source data are provided as a Source Data file.

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