Fig. 3: Targeting TNK2 suppresses tumor growth in a CD8⁺ T cell-dependent fashion.

a–c Representative pancreatic tumor images at the endpoint of indicated KPC cells orthotopic grafted into immunocompetent or CD8⁺T cell deficient C57BL/6 mice or BALB/c nude mice (n = 8 independent experiments) (a). Tumor growth curves (b) and tumor weights (c) measured at the endpoint. d Representative pancreatic tumor images at the endpoint of indicated KPC cells orthotopic transplanted into C57BL/6 mice (n = 8 independent experiments) (d). Tumor growth curves (e) and tumor weights (f) measured at the endpoint. Flow cytometry analysis showing the changes of CD8⁺ T cells (g), GzmB⁺CD8⁺ T cells (h), TNF⁺CD8⁺ T cells (i), PD-1⁺CD8⁺ T cells (j) and TIM3⁺CD8⁺ T cells (k) in each group (n = 8 independent experiments). Statistical significance was determined by two-way ANOVA followed by Tukey’s multiple comparisons test (b, e) and one-way ANOVA followed by Tukey’s multiple comparisons test (c, f–k). All tests were two sided. Data represents mean ± s.d. Source data are provided as a Source Data file.