Fig. 3: Funnel plot for LDL-cholesterol and coronary heart disease (GPAT and MR). | Nature Communications

Fig. 3: Funnel plot for LDL-cholesterol and coronary heart disease (GPAT and MR).

From: Evaluating transportability of in vitro cellular models to in vivo human phenotypes using gene perturbation data

Fig. 3: Funnel plot for LDL-cholesterol and coronary heart disease (GPAT and MR).The alternative text for this image may have been generated using AI.

Wald ratios and standard errors are plotted for gene perturbations (GPAT, left) and genetic variants (MR, right) associated with LDL-cholesterol. Each Wald ratio is an estimate of the effect of LDL-cholesterol on CHD. For example, if pLoF gene burden is associated with a 0.5 unit increase in LDL-cholesterol and a 0.2 log-odds increase in CHD risk, then the Wald ratio for the gene is 0.4. Both GPAT and MR estimates indicate that higher LDL-cholesterol increases the risk of CHD. The dashed lines represent the fixed-effects (longer bars) and random-effects (shorter bars) meta-analysis estimates and the 95% confidence intervals. For visualisation, we restricted the plot to genes with Wald Ratios less than three and Wald Ratio standard errors less than 1, which contribute the most to the overall estimates. Estimates are presented on the log odds scale in the figure and as odds ratios in the text.

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