Fig. 4: Histogram of distribution of test statistics and effect sizes for associations between pLoF burden of gene and the corresponding protein (plasma levels) pairs. | Nature Communications

Fig. 4: Histogram of distribution of test statistics and effect sizes for associations between pLoF burden of gene and the corresponding protein (plasma levels) pairs.

From: Evaluating transportability of in vitro cellular models to in vivo human phenotypes using gene perturbation data

Fig. 4: Histogram of distribution of test statistics and effect sizes for associations between pLoF burden of gene and the corresponding protein (plasma levels) pairs.The alternative text for this image may have been generated using AI.

Histograms of Z scores (left) and signed effect sizes (right) for the association between pLoF burden and encoded protein levels in plasma. The graphs indicate that pLoF lowers plasma-protein levels for most gene-protein pairs, although confidence intervals overlap the null for a substantial proportion, and there are a few outliers in the opposite direction.

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