Fig. 2: Characterisation of the SLX4-XPF interaction.
From: Molecular basis of XPF-ERCC1 targeting to SLX4-dependent DNA repair pathways
a Structures of the SLX4 fragment 526-552, with residues interacting with XPF shown as yellow sticks (left), and structure of XPF, with residues interacting with SLX4 shown as red sticks (right). The area of XPF interacting with the SLX4 helix 529-534 is marked by a dashed line. b Small-scale in-vitro co-sedimentation assay of XPF-ERCC1 with Strep-tagged SLX4330-555 wild type and 5 A mutant. c Small-scale in-vitro co-sedimentation assay of MBP-fused SLX4523-555 wild type and 5 A mutant. d Co-IP of wild type and 5A-mutant SLX4 from HEK293TN cells. 1% of input lysate to the IP was analysed as input. Source data are provided as a Source data file.
