Fig. 6: Analysis of the XPF-SLX4IP interaction.
From: Molecular basis of XPF-ERCC1 targeting to SLX4-dependent DNA repair pathways
a SLX4IP and XPF residues mediating the SLX4IP-XPF interaction are coloured green (left) and red (right), respectively. b Mapping of mutations that have been reported to disrupt the SLX4IP-XPF interaction. c Conformation of XPF in the absence of SLX4IP. d Conformation of XPF after strand exchange involving XPF residues 542–556 upon SLX4IP binding. e Interactions mediated by XPF residues 542–549. f Conformational change in XPF residues 557–573 upon binding of SLX4IP (light green: free XPF; dark green: SLX4IP-bound XPF).
