Fig. 8: Molecular basis for SMX complex assembly.
From: Molecular basis of XPF-ERCC1 targeting to SLX4-dependent DNA repair pathways
Schematic model of the SMX complex shown along with molecular structures of critical contact sites responsible for complex assembly (SLX4-MUS81: PDB ID 7BU5, SLX4-SLX1: PDB ID 4XLG)34. A second copy of the complex is shown semi-transparent to represent possible formation of a heterododecameric SMX dimer. Mechanisms for SMX nuclease activation are represented schematically.
