Fig. 4: Results of gene prioritization.
From: Revealing the genetic architectures underlying organ-specific aging based on proteomic data
a (Upper panel) The histogram shows the distribution of risk genes categorized by the number of supporting evidence. The x-axis represents the number of supporting evidence, while the y-axis shows the count of risk genes for each category. Summary of evidence categories of prioritized genes. (Bottom panel) 85 genes supported by at least 3 analysis methods in 14 traits are shown. The organs and prioritized genes are displayed on the left, and “pleiotropy” indicates whether the gene is associated with more than one aging phenotype. b The number of genes prioritized (by TWAS, COLOC, SMR, or fine-mapped SNP annotation) for each aging phenotype. c GWAS results at the ABO gene locus for pancreas, intestine, immune, artery and lung aging. The two SNPs that determined the ABO blood type were annotated. Gray dashed lines represent genome-wide significance (p < 5 × 10⁻⁸). Source data are provided as a Source Data file.
