Fig. 5: Function annotation of organ aging genes.
From: Revealing the genetic architectures underlying organ-specific aging based on proteomic data
a Enrichment of organ aging genes in gene ontology (GO) biological process. Results were generated using the R package clusterProfiler. Enrichment significance was evaluated using a two-sided Fisher’s exact test. For each organ, the top 3 most significant results are shown. b Enrichment of organ aging genes in genes related to mouse phenotypes. Only significant results (p < 0.05, two-sided Fisher’s exact test) are shown. Results are shown as log odds ratios (OR) with 95% confidence intervals (CI). Exact values from Fisher’s exact tests are provided in the Source Data file. c Gene-drug-diseases network constructed using GREP, only significant results (p < 0.05, one-sided Fisher exact test) are shown. Source data are provided as a Source Data file.
