Fig. 5: SAFV-3 specifically utilizes integrin αVβ8 of the integrin αV subfamily for infection. | Nature Communications

Fig. 5: SAFV-3 specifically utilizes integrin αVβ8 of the integrin αV subfamily for infection.

From: Saffold virus exploits integrin αvβ8 and sulfated glycosaminoglycans as cooperative attachment receptors for infection

Fig. 5: SAFV-3 specifically utilizes integrin αVβ8 of the integrin αV subfamily for infection.The alternative text for this image may have been generated using AI.

a Expression of human integrin β subunits (β1, β3, β5, and β6) on the surface of BHK-21 derivatives. BHK-21 cells lentivirally transduced with the respective integrin β subunits were stained with the indicated antibodies and analyzed using flow cytometry. b Susceptibility analysis using SAF/UnaG in human integrin αV and the indicated β subunit expressing BHK-21 cells. UnaG-positive cells (green, upper panel) and nuclei stained with Hoechst (blue, lower panel) were imaged at 16 h post-infection. Scale bar, 200 μm. Images are representative of two independent experiments.

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