Fig. 7: The role of NPF motifs in cellular processes, mediated by POLE2.
From: The non-catalytic DNA polymerase ε subunit is an NPF motif recognition protein
A Identified partners of POLE2 are involved in replication, transcriptional regulation, as well as DNA repair mechanisms. B In known replisome structures, the relative position of WDHD1 and POLE2 permits the binding of the WDHD1 NPF motifs. Such stapling would pose a flexible, yet constrained tethering of polymerases responsible for leading and lagging strand synthesis. C In the experimental density maps of published POLE2 cryo-EM structures, unexplained densities can be observed on the POLE2 surface perfectly coinciding to the NPF motif sequences docked by AF3.
